Emile Canoy on LinkedIn: Sr Staff R&D Project Manager in Eindhoven, Netherlands | Research &… (2024)

After months of sifting through potential leads, optimizing molecule structures and preparing for synthesis, the last thing you want to hear is your compound isn’t patentable.Let us help. With our early drug discovery services, you get intel that helps you make the right decisions at the right time. We can provide...* A rundown on existing therapies and molecules* A literature review to inform your compound development* Filtering of your candidate molecules for novelty, rapid commercial availability and patentable IP* Support in ensuring your leads are drug-like from the very beginning with our industry-best ADMET and HT-PK predictions integrated into the generative chemistry process. Learn more about how we can help: https://lnkd.in/gCGcxHmV

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𝗖𝗲𝗹𝗲𝗯𝗿𝗮𝘁𝗶𝗻𝗴 𝗮 𝗱𝗲𝗰𝗮𝗱𝗲 𝗼𝗳 𝘀𝘂𝗰𝗰𝗲𝘀𝘀: 𝗡𝗮𝗻𝗶𝗼𝗻 & 𝗕𝗲𝗰𝗸𝗺𝗮𝗻 𝗖𝗼𝘂𝗹𝘁𝗲𝗿 𝗟𝗶𝗳𝗲 𝗦𝗰𝗶𝗲𝗻𝗰𝗲𝘀 🤝1️⃣0️⃣🎉In 2012, Nanion Technologies embarked on a project to increase throughput and enter the high throughput arena with 𝟯𝟴𝟰 𝘀𝗶𝗺𝘂𝗹𝘁𝗮𝗻𝗲𝗼𝘂𝘀 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝗽𝗮𝘁𝗰𝗵 𝗰𝗹𝗮𝗺𝗽 𝗿𝗲𝗰𝗼𝗿𝗱𝗶𝗻𝗴𝘀 with giga-Ohm seals. With Nanion’s expertise in high-quality patch clamp, it was natural to seek a leading provider of liquid handlers to incorporate Nanion’s patch clamp module, or ‘patch engine’, making a fully-fledged, high throughput automated patch clamp instrument. At that time, the innovative Biomek FXP from Beckman Coulter Life Sciences was a reliable, highly flexible liquid handler already used in thousands of research laboratories worldwide. The adaptation of the Biomek FXP to incorporate 1 or 2 patch clamp modules was straightforward and was facilitated by the exceptional collaboration between the two companies. After less than one year of development, the 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰𝗣𝗘 was fully operational and ready to be shipped to customers in December 2013.The exceptional collaboration between Nanion and Beckman Coulter Life Sciences has been instrumental in developing the SyncroPatch 384PE. This partnership enabled the creation of a revolutionary high-throughput automated patch clamp instrument that has transformed the field of electrophysiology, with the further development of the 𝗦𝘆𝗻𝗰𝗿𝗼𝗣𝗮𝘁𝗰𝗵 𝟯𝟴𝟰 incorporating the 𝗕𝗶𝗼𝗺𝗲𝗸 𝗶𝟱 𝗹𝗶𝗾𝘂𝗶𝗱 𝗵𝗮𝗻𝗱𝗹𝗲𝗿. The future of automated patch clamp recording looks brighter than ever before 🔆 Read the full Press Release and find out more about the history of SyncroPatch 384 and our partnership with Beckman Coulter Life Sciences: https://ow.ly/B54A50QhoeN#PressRelease #SyncroPatch384 #APC #Electrophysiology #Biomeki5 #AutomatedPatchClamp #Ionchannels #Partnership

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What does it take to plan and move a laboratory?Read our blog to find out our top 6 tips!Restore Harrow Green Laboratory Services are here to assist you as and when you need us.#laboratory #research #pharma #logistics #projectmanagement

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Join us for our last free webinar for this year! Arpad Forberger, PhD is going to talk about the use of simulation in Pharma and Biotech industries. During the session he will demonstrate how you can optimize biopharmaceutical processes, and model a rapid detection test in COMSOL Multiphysics. You can register here to reserve your spot: https://bit.ly/41aawcn #pharmaceutical #pharma #biopharmaceutical #simulation #multiphysics

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🚀 𝐄𝐯𝐨𝐧𝐢𝐤 𝐃𝐫𝐮𝐠 𝐒𝐮𝐛𝐬𝐭𝐚𝐧𝐜𝐞 - 𝐎𝐩𝐭𝐢𝐦𝐢𝐳𝐢𝐧𝐠 𝐀𝐏𝐈 𝐚𝐧𝐝 𝐈𝐧𝐭𝐞𝐫𝐦𝐞𝐝𝐢𝐚𝐭𝐞 𝐅𝐢𝐥𝐭𝐫𝐚𝐭𝐢𝐨𝐧!🧪Isolating solid materials with the desired properties during the crystallization process is crucial in API and intermediate manufacturing. Achieving the right crystallinity, purity, mechanical properties, particle size, and shape is a challenge in the manufacturing process. At Evonik, we understand this challenge and have a team of expert developers, advanced processing equipment, and analytical tools onsite to optimize the isolation and filtration of your API and intermediates.We have successfully optimized our partners' processes, enhancing filtration efficiency without requiring any registration changes, even in the late-stage and commercial process stages. With Evonik by your side, you can trust that your manufacturing processes will be optimized for success.#smallmolecules#pharmaceuticalmanufacturing#biotechnology#hpapi#api#cdmo#drugdevelopment#CMO#biopharma#Sustainability#Innovation#pharmaceuticals#drugspharmaceuticals #ParticleEngineeringhttps://lnkd.in/geaCXZrS

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Curious about the next generation of liquid crystal materials available to academic researchers and start-ups? EMD Electronics are thrilled to announce the launch of our next generation R&D liquid crystals, specifically designed to meet the unique needs of academia and start-ups. Our expert R&D team has developed a new line of liquid crystals that offer advanced optical properties, making them an ideal tool for research opportunities and teaching optics principles. We are excited to partner with researchers and educators to support their ongoing efforts and see how these new liquid crystals can impact future liquid crystal applications. If you're interested in learning more about our new line of liquid crystals or have any questions about how they can benefit your research or teaching, please don't hesitate to contact us @https://lnkd.in/g99vm-mM#EMDElectronics#liquidcrystal#LCtechnology#future#digitaloptics#materials#futuredisplays#learning#researchanddevelopment#academia

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🔬Here's our application note highlighting the impact of picodroplet microfluidics in single-cell analysis and cell engineering. Picodroplet technology is helping researchers by encapsulating single cells in picoliter-volume aqueous droplets at high throughput, enabling:• High-throughput workflow for analysing hundreds of thousands to millions of cells.• A controlled microenvironment for individual cell engineering and characterisation.• Higher detection sensitivity due to concentrated volumes.• Reduced reagent costs through miniaturisation.• Streamlined workflows with integration and automation.• A cell-friendly culturing environment for varying lengths of time.From compatibility with different transfection reagents to genome editing using CRISPR-Cas9, our technologies are improving efficiency and precision in cell engineering. It also plays a pivotal role in alleviating the challenges associated with traditional antibody discovery and cell line development techniques, and many other applications.🔗 Check it out here: https://lnkd.in/epZw56Vc#cellengineering #crispr #biopharma #celllinedevelopment #antibodydiscovery #biologics #microfluidics #picodroplet #cytomine #spherefluidics

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Have you got an upcoming laboratory relocation?Read our blog to get some helpful tips!

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Mixing is a critical consideration of scaling up new drug substances and can be the cause of a string of issues that can ultimately delay medicine getting to patients. Being able to advance the way we evaluate mixing for both scale up and at commercial scale, is crucial to ensure successful first time manufacturing processes that allow patients to get their medicine on time, for the lowest cost and lowest environmental footprint.This week I went to Porto for the Mixing17 conference, a conference since 1974 that brings together leading experts across the globe to showcase new research and case studies in the world of mixing.Personal highlights were hearing about the advancements in CFD modelling, including applications of Lattice Boltzmann, Large Eddy Simulation method and the development of new validated case studies. In addition, hearing about the great examples of experimental model validation using new and already established techniques gave a good insight into ways to validate our digital solutions and I’d like to see some of these techniques bridged over from academia to industry. Methods include Particle Tracking Velocimetry (PTV), Particle Image Velocimetry (PIV), Electrical Resistance Tomography (ERT), Positron Emission Particle Tracking (PEPT) and Planar Laser-induced Fluorescence (PLIF). The standout presentation of course was learning about the port manufacturing process, one of the many benefits of hosting a mixing conference in Porto…!🍷Looking forward to bring these ideas back to the drug development process 💊What does resolution really mean in a Large Eddy Simulation (LES)? M-Star CFD https://lnkd.in/e9UF7_8c

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At Concept Life Sciences, we offer integrated drug discovery & development from Concept through to Clinic. For small molecule assets, a critical part of that journey is synthetic chemistry, split between small scale analogue synthesis for medicinal chemistry screening, large scale manufacturing to produce enough material for toxicity/efficacy studies and process research & development to bridge the gap.Our Senior Chemists Brian Broadbelt and Neringa Tamosiunaite have recently contributed to the development of a synthetic route towards lotiglipron, a Glucagon-Like Peptide-1 (GLP-1) receptor agonist with future large scale manufacturing in mind, given the recent success of current marketed therapies: https://lnkd.in/eKm7NNQj.The aim of the collaboration was to support development of a benzodioxole-ketone, a key building block in the synthesis of lotiglipron. Specifically, our team were set a target of delivering a 100 g scale synthesis of the intermediate salt in >50% yield. The Concept Life Sciences team contributed to the successful project outcome in several ways:·Contributing to the post-high throughput experimentation (HTE) optimisation of the reaction between a catechol and methyl 2,2-dichloropropanoate. Slow addition of the catechol to the reaction mixture and elevated reaction temperature facilitated an increase in yield.·Contributing to the post-high throughput experimentation (HTE) salt screen of the above reaction. Addition of MTBE increased the isolation yield.Our work exceeded the client’s target, we were able to convert 100 g of the catechol starting material into 168 g of the intermediate salt in 68% yield. We also played a role in transforming the salt into the benzodioxole-ketone by:·Developing a salt-break protocol.·Developing a telescoped end-game process by identifying 2-MeTHF as the optimal solvent for both Weinreb amide formation and attack by methylmagnesium bromide.Overall, our work supported the decagram scale synthesis of the benzodioxole-ketone building block and paved the way for potential future scale up campaigns. Brian Broadbelt, Neringa Tamosiunaite and the rest of our team excel at these types of workflows. If you could benefit from their knowledge and experience, we would love to hear from you: https://lnkd.in/dKpT6Nn#Concept2Clinic#SyntheticChemistry #ProcessDevelopment#Pharmaceuticals#DrugDiscovery

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